Blar i forfatter "Julin, Kjersti"

Viser treff 1-8 av 8

    • Biofilm Responsive Zwitterionic Antimicrobial Nanoparticles to Treat Cutaneous Infection 

      Obuobi, Sybil Akua Okyerewa; Phung, Anna Ngoc; Julin, Kjersti; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
      To avert the poor bioavailability of antibiotics during S. aureus biofilm infections, a series of zwitterionic nanoparticles containing nucleic acid nanostructures were fabricated for the delivery of vancomycin. The nanoparticles were prepared with three main lipids: (i) neutral (soy phosphatidylcholine; P), (ii) positively charged ionizable (1,2-dioleyloxy-3-dimethylaminopropane; D), and (iii) ...

    • Chitosan-based delivery system enhances antimicrobial activity of chlorhexidine 

      Hemmingsen, Lisa Myrseth; Panchai, Pimmat; Julin, Kjersti; Basnet, Purusotam; Nystad, Mona; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-29)
      Infected chronic skin wounds and other skin infections are increasingly putting pressure on the health care providers and patients. The pressure is especially concerning due to the rise of antimicrobial resistance and biofilm-producing bacteria that further impair treatment success. Therefore, innovative strategies for wound healing and bacterial eradication are urgently needed; utilization ...

    • Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control 

      Hemmingsen, Lisa Myrseth; Julin, Kjersti; Ahsan, Luqman; Basnet, Purusotam; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-12)
      Burns and other skin injuries are growing concerns as well as challenges in an era of antimicrobial resistance. Novel treatment options to improve the prevention and eradication of infectious skin biofilm-producing pathogens, while enhancing wound healing, are urgently needed for the timely treatment of infection-prone injuries. Treatment of acute skin injuries requires tailoring of formulation to ...

    • Exploring differentially expressed genes of Staphylococcus aureus exposed to human tonsillar cells using RNA sequencing 

      Bastakoti, Srijana; Ajayi, Clement; Julin, Kjersti; Johannessen, Mona; Hanssen, Anne Merethe (Journal article; Tidsskriftartikkel, 2023-07-12)
      Background - The nose and the throat are the most predominant colonizing sites of Staphylococcus aureus, and colonization is a risk factor for infection. Nasal colonization is well described; however, we have limited knowledge about S. aureus throat colonization. The main objective of this study was to explore differentially expressed genes (DEGs) in S. aureus throat isolate TR145 exposed to human ...

    • Infectious pancreatic necrosis virus (IPNV) - Persistent infections, virulence and antiviral defence 

      Julin, Kjersti (Doctoral thesis; Doktorgradsavhandling, 2015-02-06)
      Infeksiøs pankreas nekrose (IPN) er en fiskesykdom som rammer mange fiskeslag over store deler av verden. Det har store økonomiske konsekvenser for norsk lakseoppdrettsnæring. Infeksiøs pankreas nekrose var først kjent som en sykdom i yngel, men i de siste 10 til 20 årene har det vært et like stort problem i post-smolt. Antall utbrudd varierer fra år til år, der 2009 ble registrert som et år med ...

    • Liposomal delivery of antibiotic loaded nucleic acid nanogels with enhanced drug loading and synergistic anti-inflammatory activity against S. aureus intracellular infections 

      Obuobi, Sybil Akua Okyerewa; Julin, Kjersti; Fredheim, Elizabeth G. Aarag; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-07)
      The persistence of <i>Staphylococcus aureus</i> has been accredited to its ability to escape immune response via host cell invasion. Despite the efficacy of many antibiotics against <i>S. aureus</i>, the high extracellular concentrations of conventional antibiotics required for bactericidal activity is limited by their low cellular accumulation and poor intracellular retention. While nanocarriers ...

    • Polymyxin B stabilized DNA micelles for sustained antibacterial and antibiofilm activity against P. aeruginosa 

      Antunes de Sousa, Alexandra Sofia; Borøy, Vegard; Bæverud, Agnethe Hansen; Julin, Kjersti; Bayer, Annette; Strøm, Morten B.; Johannessen, Mona Susan; Skalko Basnet, Natasa; Obuobi, Sybil Akua Okyerewa (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-21)
      Nucleic acid-based materials showcase an increasing potential for antimicrobial drug delivery. Although numerous reports on drug-loaded DNA nanoparticles outline their pivotal antibacterial activities, their potential as drug delivery systems against bacterial biofilms awaits further studies. Among different oligonucleotide structures, micellar nanocarriers derived from amphiphilic DNA strands ...

    • The Antimicrobial Properties of Chitosan Can be  Tailored by Formulation 

      Jøraholmen, May Wenche; Bhargava, Abhilasha; Julin, Kjersti; Johannessen, Mona; Skalko-Basnet, Natasa (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-31)
      Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in improving localized vaginal therapy by prolonging the residence time of a drug at ...